As a thumb rule , you will generally lost the connections to QMGR at some point for one reason or another and it often the case that the root cause of the disconnection is undetermined.
The item you an application control is making sure that we add auto reconnect login to your application , so these disconnects do no cause business impact or require manual intervention form the application team,
Based on the experience it is strongly recommended that application team to code with auto reconnect login to avoid these type of issues in the future.